Speaker: Jin Jun
Day:  Wednesday, 10/25/2006
Room: ITEB 201
Time: 3:00pm

Title: Off-target search algorithm for siRNA

Abstract.
Designing highly effective short interfering RAN (siRNA) sequences with maximum target-specificity for RNA interference (RNAi) is one of the hottest topics in molecular biology. So there is a pressing need to compute siRNA sequences that minimize off-target silencing effects efficiently and to match any non-targeted sequences with mismatches.  The enumeration of potential cross-hybridization candidates is non-trivial because siRNA sequences are short and at least three mismatches with non-targets are required.  To solve this problem, non-overlapping and overlapping window-based algorithms are suggested.

Reference : Bioinformatics, Vol.21, No.8, Pp.1316-1324, 2005.